Autophagy's role in DNA loss and survival of diploid yeast cells during chronological aging

Originally published by Impact Journals LLC on October 25, 2023

Autophagy contributes to cells’ survival during chronological aging. Credit: Aging (2023). DOI: 10.18632/aging.205102

A new research paper titled "Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging" has been published in Aging.

Aging is inevitable and affects all cell types. Thus, yeast cells are often used as a model in aging studies. There are two approaches to studying aging in yeast: replicative aging, which describes the proliferative potential of cells, and chronological aging, which is used for studying post-mitotic cells.

In this new study, while analyzing the chronological lifespan (CLS) of diploid Saccharomyces cerevisiae cells, researchers Tuguldur Enkhbaatar, Marek Skoneczny, Karolina Stępień, Mateusz Mołoń, and Adrianna Skoneczna from the Polish Academy of Sciences and Rzeszów University discovered a remarkable phenomenon: ploidy reduction during aging progression.

"To uncover the mechanism behind this unusual process we used yeast strains undergoing a CLS assay, looking for various aging parameters," the researchers explain.

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