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Originally published by Eötvös Loránd University on August 26, 202   N 6 -methyladenine levels in the C. elegans mitochondrial genome gradually increase with age. (A) The 6mA progressively accumulates at different mtDNA sites (mito 3 and mito 4) during aging. (A’) Quantification of the relative mtDNA 6mA levels at different adult stages. Bars indicate ±S.D.; each comparison reveals ***: p < 0.001 significance. Credit: International Journal of Molecular Sciences (2023). DOI: 10.3390/ijms241914858 Building on their work on epigenetics of aging and transposable elements, researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University have made another advance in understanding the molecular mechanisms of aging . Their latest study, published in the International Journal of Molecular Sciences , reveals a novel epigenetic mechanism in mitochondrial DNA (mtDNA) that could transform our approach to aging research and diagnostics . In their previous articles , " T...

Originally published by Impact Journals LLC on October 25, 2023 Autophagy contributes to cells’ survival during chronological aging. Credit: Aging (2023). DOI: 10.18632/aging.205102 A new research paper titled "Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging " has been published in Aging . Aging is inevitable and affects all cell types. Thus, yeast cells are often used as a model in aging studies. There are two approaches to studying aging in yeast : replicative aging , which describes the proliferative potential of cells, and chronological aging , which is used for studying post-mitotic cells. In this new study, while analyzing the chronological lifespan (CLS) of diploid Saccharomyces cerevisiae cells, researchers Tuguldur Enkhbaatar, Marek Skoneczny, Karolina Stępień, Mateusz Mołoń, and Adrianna Skoneczna from the Polish Academy of Sciences and Rzeszów University discovered a remar...