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Originally published by University of Nottingham, on November 8, 2023 Saccharomyces cerevisiae, SEM image. Credit: Mogana Das Murtey and Patchamuthu Ramasamy/CC BY-SA 3.0 A UK-based team of Scientists, led by experts from the University of Nottingham and Imperial College London , have completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome . The work, which is published in Cell Genomics , represents completion of one of the 16 chromosomes of the yeast genome by the UK team, which is part of the biggest project ever in synthetic biology ; the international synthetic yeast genome collaboration. The collaboration , known as " Sc2.0 " has been a 15-year project involving teams from around the world (UK, US, China, Singapore, UK, France and Australia), working together to make synthetic versions of all of yeast's chromosomes . Alongside this paper, another nine publications h...

Originally published by Impact Journals LLC on October 25, 2023 Autophagy contributes to cells’ survival during chronological aging. Credit: Aging (2023). DOI: 10.18632/aging.205102 A new research paper titled "Live while the DNA lasts. The role of autophagy in DNA loss and survival of diploid yeast cells during chronological aging " has been published in Aging . Aging is inevitable and affects all cell types. Thus, yeast cells are often used as a model in aging studies. There are two approaches to studying aging in yeast : replicative aging , which describes the proliferative potential of cells, and chronological aging , which is used for studying post-mitotic cells. In this new study, while analyzing the chronological lifespan (CLS) of diploid Saccharomyces cerevisiae cells, researchers Tuguldur Enkhbaatar, Marek Skoneczny, Karolina Stępień, Mateusz Mołoń, and Adrianna Skoneczna from the Polish Academy of Sciences and Rzeszów University discovered a remar...