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Originally published by Bruno Geoffroy, University of Montreal , on February 25, 2025   Credit: Developmental Cell (2025). DOI: 10.1016/j.devcel.2025.01.002 Sister cells are a pair of cells that share the same mother cell. In a new study published in Developmental Cell , researchers led by Université de Montréal (UdeM) professor Greg FitzHarris show how the early mouse embryo gets rid of the defective or unneeded cells in pairs. "Such a mechanism could serve to ensure the elimination of cells with a common adverse history, such as DNA damage or aneuploidy, an abnormal number of chromosomes in cells known to be one of the main causes of infertility," said FitzHarris, a researcher at the UdeM-affiliated hospital research center, the CRCHUM. In the new study, first author Filip Vasilev, a former postdoctoral fellow in FitzHarris' laboratory, shows that abscission, the final step of cell division, is delayed in the early mouse embryo, leaving sister cells connected ...

Scientists identify a signaling pathway that triggers muscle fatigue in response to nervous system inflammation or infections like SARS-CoV-2. Originally published by Sneha Khedkar at The Scientist, on Jan 21, 2025 ABOVE: Nervous system infection or inflammation trigger brain-muscle signaling pathways that cause muscle fatigue. ©iStock,  Chinnapong In 2020, as the COVID-19 pandemic escalated, many universities shut down or reduced the capacities of research laboratorie s in an attempt to limit the spread of the virus. At Washington University School of Medicine in St. Louis , developmental biologist Aaron Johnson was permitted one person in his lab to keep things running. Shuo Yang , then a postdoctoral researcher working on muscle developmental biology, stepped up. An immunologist by training, Yang, now at Fudan University, was curious to learn more about the virus that was wreaking havoc in the world. Since h is model organism—the fruit fly—was not naturally susce...

The large nerve cord running down each octopus arm is separated into segments, giving it precise control over movements and creating a spatial map of its suckers. Originally published by By Matt Wood, Assistant Director of Communications, Biological Sciences Division, University of Chicago on January 15, 2025 Octopus bimaculoides. Credit: Cassady Olson Octopus arms move with incredible dexterity, bending, twisting, and curling with nearly infinite degrees of freedom. New research from the University of Chicago revealed that the nervous system circuitry that controls arm movement in octopuses is segmented, giving these extraordinary creatures precise control across all eight arms and hundreds of suckers to explore their environment, grasp objects, and capture prey. "If you're going to have a nervous system that's controlling such dynamic movement, that's a good way to set it up," said Clifton Ragsdale, Ph.D., Professor of Neurobiology at UChicago and seni...

Groundbreaking research uncovers the origins of the ventral nerve cord in early moulting animals Originally published by by Queen Mary, University of London , on:13 January 2025 Tubular incomplete specimens of Eopriapulites sphinx from the early Cambrian Kuanchuanpu Formation, showing their ventral nerve cord. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adr0896 An international team of scientists has uncovered a fascinating piece of the evolutionary puzzle: how the ventral nerve cord , a key component of the central nervous system, evolved in ecdysozoan animals , a group that includes insects, nematodes, and priapulid worms. Their findings , published in Science Advances , provide valuable insights into the origins of these structures in the basal Cambrian period .  The research team, comprising Dr Deng Wang (Northwest University), Dr Jean Vannier (Université de Lyon), Dr Chema Martin-Durán (Queen Mary University of London), and Dr María Herranz (Rey ...