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Researchers define protocol for high-resolution imaging of living cells using atomic force microscopy

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  Originally published by Kanazawa Universit at www.phys.org, on September 5, 2023 Overview of the method for observing actin fibers in living cells using nanoendoscopy-AFM. Credit: STAR Protocols (2023). DOI: 10.1016/j.xpro.2023.102468 Images of nanoscale structures inside living cells are in increasing demand for the insights into cellular structure and function that they can reveal. So far, the tools for capturing such images have been limited, but researchers led by Takeshi Fukuma and Takehiko Ichikawa at Kanazawa University have now devised and reported a full protocol for using atomic force microscopy (AFM) to image inside living cells . The research is published in the journal STAR Protocols . AFM was first developed in the 1980s and uses the changes in the forces between a sample surface and a nanoscale tip attached to a cantilever to identify surfaces and produce images of the topography with nanoscale resolution. The technique has grown increasingly sophistica...
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Discovery of chemical means to reverse aging and restore cellular function

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Originally published by Impact Journals LLC on July 13, 2023   Reprogramming small molecule cocktails restore NCC alterations in senescent cells. (A) Chemical structures of small molecules of basal cocktails used to generate induced pluripotent stem cells (iPSCs) from mouse (left) or human (right) somatic cells. (B) Correlation heatmaps showing eGFP and mCherry colocalization in human senescent fibroblasts demonstrate the effects of 80 different combinations of small molecules (n=2). (C, D) Validation of six selected cocktails through independent experiments, showing colocalization (C) and representative images (D) of eGFP and mCherry signals. Scale bar, 50 μm. Data are mean ± SD. *p < 0.05; **p < 0.01; ****p < 0.0001. One-way ANOVA-Bonferroni. Credit: Aging (2023). DOI: 10.18632/aging.204896 In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age -related diseases . The study, conducted by a team of scientists at Harvard M...
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Mapping ATP's journey: Key protein identified as gateway for energy delivery into endoplasmic reticulum

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Originally published by Stockholm University on May 21, 2025 edited by Sadie Harley , reviewed by Robert Egan   Scientists reveal how ATP is transported into the ER by the protein SLC35B1. Credit: Surabhi Kokane using Biorender. A team of scientists has answered a long-standing question in cell biology , uncovering h ow the cell's main energy currency, ATP , is transported into the endoplasmic reticulum ( ER ) . Disrupted energy transport could affect diseases such as type 2 diabetes, cancer, and neurodegenerative disorders . The study, " Step-wise ATP translocation into the ER by human SLC35B1 " published in Nature , confirms that the transporter protein SLC35B1 is the key gateway for ATP entry into the ER . The research , led by David Drew, professor of biochemistry at Stockholm University and located at SciLifeLab , reveals the first structural and mechanistic insight into how ATP enters the endoplasmic reticulum (ER) using the transporter protein SL...
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