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Researchers define protocol for high-resolution imaging of living cells using atomic force microscopy

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  Originally published by Kanazawa Universit at www.phys.org, on September 5, 2023 Overview of the method for observing actin fibers in living cells using nanoendoscopy-AFM. Credit: STAR Protocols (2023). DOI: 10.1016/j.xpro.2023.102468 Images of nanoscale structures inside living cells are in increasing demand for the insights into cellular structure and function that they can reveal. So far, the tools for capturing such images have been limited, but researchers led by Takeshi Fukuma and Takehiko Ichikawa at Kanazawa University have now devised and reported a full protocol for using atomic force microscopy (AFM) to image inside living cells . The research is published in the journal STAR Protocols . AFM was first developed in the 1980s and uses the changes in the forces between a sample surface and a nanoscale tip attached to a cantilever to identify surfaces and produce images of the topography with nanoscale resolution. The technique has grown increasingly sophistica...
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Mapping ATP's journey: Key protein identified as gateway for energy delivery into endoplasmic reticulum

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Originally published by Stockholm University on May 21, 2025 edited by Sadie Harley , reviewed by Robert Egan   Scientists reveal how ATP is transported into the ER by the protein SLC35B1. Credit: Surabhi Kokane using Biorender. A team of scientists has answered a long-standing question in cell biology , uncovering h ow the cell's main energy currency, ATP , is transported into the endoplasmic reticulum ( ER ) . Disrupted energy transport could affect diseases such as type 2 diabetes, cancer, and neurodegenerative disorders . The study, " Step-wise ATP translocation into the ER by human SLC35B1 " published in Nature , confirms that the transporter protein SLC35B1 is the key gateway for ATP entry into the ER . The research , led by David Drew, professor of biochemistry at Stockholm University and located at SciLifeLab , reveals the first structural and mechanistic insight into how ATP enters the endoplasmic reticulum (ER) using the transporter protein SL...
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First map of every neuron in an adult brain has been produced for a fruit fly

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Originally published by UK Research and Innovation on October 2, 2024   3D rendering of all ~140k neurons in the fruit fly brain. Credit: Data source: FlyWire.ai; Rendering by Philipp Schlegel (University of Cambridge/MRC LMB). The first wiring diagram of every neuron in an adult brain and the 50 million connections between them has been produced for a fruit fly . This landmark achievement has been conducted by a large international collaboration of scientists , called the FlyWire Consortium , including researchers from the MRC Laboratory of Molecular Biology ( in Cambridge, UK ), Princeton University, the University of Vermont and the University of Cambridge . It is published in a pair of papers in Nature . The diagram of all 139,255 neurons in the adult fly brain is the first of an entire brain for an animal that can walk and see . Previous efforts have completed the whole brain diagrams for much smaller brains , for example, for that of a fruit fly larva, whi...
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