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Originally published by The Scripps Research Institute, on May 22, 2024   A tiny glass tube (top left) represents the electrode recording from an excitatory human Alzheimer's neuron, generated using modern stem cell techniques (dark blue, at tip of tube). Credit: Scripps Research According to the US Centers for Disease Control and Prevention , at least 5.8 million Americans are currently living with Alzheimer's disease, which is the most common form of dementia. There is no cure for Alzheimer's, in part because scientists do not yet have a full understanding of what causes the disease. But a new study from Scripps Research is shedding light on the molecular drivers that could contribute to Alzheimer's progression. In the study, published in Advanced Science , the researchers used a new technique for studying single, living brain cells affected by Alzheimer's disease. By measuring the electrical activity of single neurons and the protein levels within ...

Originally published by Justin Jackson , Medical Xpress, on July 6, 2023   Thinking about the time. Credit: Freeimages.com Researchers at Washington University School of Medicine in St. Louis have identified proteomic changes associated with forms of Alzheimer's disease (AD) . In a paper, "Proteomics of brain, CSF, and blood identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease ," published in Science Translational Medicine , the researchers identify specific and shared proteomic changes associated with sporadic Alzheimer's disease (AD) across brain tissue, cerebrospinal fluid (CSF), and blood . ...