Researchers pioneer production of CAR T-cells using high-density microfluidic bioreactor
Originally published by Singapore-MIT Alliance for Research and Technology on June 27, 2024 SMART researcher Dr. Wei-Xiang Sin holding the microfluidic chip within which T cells are activated, transduced, and expanded in a 2 milliliter growth chamber. Credit: SMART CAMP Researchers have developed a novel method capable of producing clinical doses of viable autologous chimeric antigen receptor (CAR) T-cells in a ultra-small automated closed-system microfluidic chip , roughly the size of a pack of cards. The team from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART) , MIT's research enterprise in Singapore , collaborated with researchers from Duke-NUS Medical School (Duke-NUS), Institute of Molecular and Cell Biology (IMCB) at the Agency for Science, Technology and Research (A*STAR) , KK Women's & Children's Hospital (KKH) and Singapore Ge