3D structure of key membrane repair proteins revealed by cryo-electron microscopy

Originally published by Universitätsmedizin Göttingen, on May 28, 2025

edited by Gaby Clark, reviewed by Robert Egan

Cryo-EM micrograph (left) of myoferlin particles (with one particle highlighted circle). 3D reconstruction of the myoferlin structure (right), with compact ring-like arrangement of the various key domains (colored) achieved upon membrane binding. Credit: Biological Reviews (2025). DOI: 10.1111/brv.70032

Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy.

The findings enable new approaches for the development of targeted drugs for the treatment of diseases such as muscle atrophy, hearing disorders and certain cancers. The results have been published in The EMBO Journal.

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