A railroad of cells: Computer simulations explain cell movement

Originally published by the Institute of Science and Technology Austria, on June 19, 2024

Snapshots of the cell railroad. Cells stretch away from a fish scale (left) into artificial lanes (red) and form trains (middle) in different sizes (right). Credit: Vercurysse, Brückner et al./Nature Physics

Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks. The cells navigate through complex environments. A new approach by researchers involving the Institute of Science and Technology Austria (ISTA) now shows how they do this and how they interact with each other. The experimental observations and the following mathematical concept are published in Nature Physics.

The majority of the cells in the human body cannot move. Some specific ones, however, can go to different places. For example, in wound healing, cells move through the body to repair damaged tissue. They sometimes travel alone or in different group sizes.

Although the process is increasingly understood, little is known about how cells interact while traveling and how they collectively navigate the complex environments found in the body. An interdisciplinary team of theoretical physicists at the Institute of Science and Technology Austria (ISTA) and experimentalists from the University of Mons in Belgium now has new insights.

Much like social dynamics experiments, where understanding the interactions of a small group of people is easier than analyzing an entire society, the scientists studied the traveling behavior of a small group of cells in well-defined in vitro surroundings, i.e. outside a living organism, in a Petri dish equipped with interior features. Based on their findings, they developed a framework of interaction rules.

Read more

Comments

Post a Comment

Popular posts from this blog

First map of every neuron in an adult brain has been produced for a fruit fly

Image
Originally published by UK Research and Innovation on October 2, 2024   3D rendering of all ~140k neurons in the fruit fly brain. Credit: Data source: FlyWire.ai; Rendering by Philipp Schlegel (University of Cambridge/MRC LMB). The first wiring diagram of every neuron in an adult brain and the 50 million connections between them has been produced for a fruit fly . This landmark achievement has been conducted by a large international collaboration of scientists , called the FlyWire Consortium , including researchers from the MRC Laboratory of Molecular Biology ( in Cambridge, UK ), Princeton University, the University of Vermont and the University of Cambridge . It is published in a pair of papers in Nature . The diagram of all 139,255 neurons in the adult fly brain is the first of an entire brain for an animal that can walk and see . Previous efforts have completed the whole brain diagrams for much smaller brains , for example, for that of a fruit fly larva, which h
Read more

Research finds resin that destroys coronavirus on plastic surfaces

Image
O riginally published by University of Jyväskylä, on January 30, 2024 Studying the impact of rosin-functionalized plastic and standard LDPE on the structure of HCoV-OC43 using (A) TEM and (B) AFM in liquid. The scale bar corresponds to 100 nm and 1 µm in the TEM and AFM images, respectively. In panel B, the blue circle highlights a doughnut-shaped virus. (C) The histogram derived from the AFM images illustrates the average size distribution of the height of individual viruses after being flushed from their respective surfaces. Credit: Microbiology Spectrum (2024). DOI: 10.1128/spectrum.03008-23 Researchers at the University of Jyväskylä, Finland , are currently developing anti-viral surfaces to decrease the spread of infectious diseases. A recent study published in Microbiology Spectrum found that a resin ingredient is effective against coronaviruses and strongly decreases their infectivity on plastic surfaces. Viruses may persist on solid surfaces for long periods, which ma
Read more

Engineered Rabies Virus Illuminates Neural Circuitry

Image
Originally published by Hannah Thomasy, PhD, for the Scientist on June 14, 2024 Scientists turned a deadly virus into a crucial tool for understanding the wiring of the brain.   Rabies labeling helps scientists identify neurons in the primary visual cortex that connect to two different higher visual brain regions. Marina Garrett  In 1906 , pathologist Camillo Golgi and neuroscientist Santiago Ramón y Cajal won the Nobel Prize for their work on the structure of the nervous system . More than a century later, the puzzle of nervous system organization —the intricately tangled mess that results from each neuron’s connections to thousands of others— remains incomplete . Yet, fully developing scientific understanding of these connections is crucial , said Edward Callaway , a systems neurobiologist at the Salk Institute . “If you don’t have some knowledge about how the different parts are interacting , there’s no way to generate a hypothesis about how they’re working together .”  N
Read more