New tool helps decipher gene behavior

Originally published by Kyoto University, on February 28,2024

 

'epidecodeR' is a tool that can streamline the analysis of complex epigenome and epitranscriptome data, allowing for the rapid and accurate prediction of the effects of epimarks on gene expression. Credit: Mindy Takamiya/Kyoto University iCeMS

Scientists have extensively researched the structure and sequence of genetic material and its interactions with proteins in the hope of understanding how our genetics and environment interact with diseases. This research has partly focused on 'epigenetic marks,' which are chemical modifications to DNA, RNA, and the associated proteins (known as histones).

Epigenetic marks influence when and how genes get switched on or off. They can also instruct cells about how to interpret and use genetic information, influencing various cellular processes. Changes in epigenetic marks, therefore, significantly impact gene regulation and cellular functions, which means they might contribute to disease. By studying epigenetic marks, researchers can clarify their role in health and disease and potentially discover new avenues for treatment.

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