Machine learning reveals behaviors linked with early Alzheimer's, points to new treatments
Originally published at MedicalXpress by Gladstone Institutes , on November 26, 2024 Aged App NL-G-F mice show robust AD-related pathology and mild impairments in the Morris water maze. Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114870 Subtle signs of Alzheimer's disease can emerge decades before a diagnosis —often in the form of irregular behaviors that reflect very early stages of brain dysfunction . But until now, identifying and measuring these slight behavioral changes in a scientific way hasn't been feasibl e, not even when studying Alzheimer's in mice. In a study published in Cell Reports , a team of scientists at Gladstone Institutes used a new video-based machine learning tool to pinpoint otherwise-undetectable signs of early disease in mice that were engineered to mimic key aspects of Alzheimer's. Their work sheds light on a new strategy for identifying neurological disease earlier than currently possible and tracking how it develo...