BiotechNews1

Originally published By Patrick Pester in LiveScience on October 6, 2025 The 2025 Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their work on how our immune system is prevented from attacking our organs. The 2025 Nobel Prize for Physiology or Medicine winners, Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi, pioneered the field of peripheral immune tolerance . (Image credit: © The Nobel Committee for Physiology or Medicine. Ill. Mattias Karlén) A trio of researchers has won the 2025 Nobel Prize in Physiology or Medicine for discovering how the immune system is prevented from attacking our own bodies . Mary E. Brunkow of the Institute for Systems Biology in Seattle , Fred Ramsdell of Sonoma Biotherapeutics in San Francisco , and Shimon Sakaguchi of Osaka University in Japan were awarded the prize " for their discoveries concerning peripheral immune tolerance ." The Nobel Assembly at Karol...

Originally published by Delthia Ricks , Medical Xpress, on December 28, 2023 P resence of Tcf7+ CD8+ T cells during the primary response to infection. (A) Experimental schematic: Naïve P14 cells (CD45.2) were transferred into congenically distinct B6 mice (CD45.1) that were subsequently infected with LCMV (Arm or WE strain). On the indicated day of infection, P14 cells present in the spleen (unless indicated otherwise) were characterized using flow cytometry. (B) Live cells were gated using FSC-A and SSC.A, followed by doublet discrimination using FSC-H/FSC-A. Next, singlets were gated for alive cells, CD8+ and congenic markers CD45.1 and CD45.2 were used to gate P14 cells. Credit: Science Immunology (2023). DOI: 10.1126/sciimmunol.adh3113 One of the more rigorous debates in immunology has centered on the origin of an enigmatic T cell population that possesses properties imparting memory and stem cell–like qualities, but facts about their genesis were so elusive that debate h...