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A large language model can design and troubleshoot CRISPR protocols from scratch, allowing first-time researchers to achieve up to 90 percent editing efficiency. Originally written by Rebecca Roberts, PhD, for The Nutshell section of The Scientist, on Aug 5, 2025 CRISPR-GPT was trained on over a decade of expert discussions and evaluated against almost 300 test cases.   Image credit:©iStock, Shinsei Motions CRISPR technology has revolutionized biology , largely because of its simplicity compared to previous gene editing techniques . However, it still takes weeks to learn, design, perform, and analyze CRISPR experiments; first-time CRISPR users often end up with low editing efficiencies and even experts can make costly mistakes. In a new study, researchers from S tanford University , Princeton University , and the University of California, Berkeley , teamed up with Google DeepMind to create CRISPR-GPT, an artificial intelligence (AI) tool that can guide researchers through...

An infant with a severe genetic condition has shown signs of improvement after receiving a gene-editing treatment tailored to his specific mutation Originally published   by Michael Le Page at newscientist.com on 15 May 2025 Baby KJ after a gene-editing infusion with researchers Rebecca Ahrens-Nicklas and Kiran Musunuru Children’s Hospital of Philadelphia A baby boy with a life-threatening genetic condition has become the first person to receive a bespoke CRISPR gene-editing treatment , giving a glimpse into what t he future of medicine might look like. It’s the first time anyone has been given a gene-editing treatment designed t o correct a disease-causing mutation found only in that individual, Rebecca Ahrens-Nicklas at the Children’s Hospital of Philadelphia, Pennsylvania , told a press briefing. “He’s showing some early signs of benefit,” she says, but it is too soon to tell how well the treatment worked. The researchers published the details as soon as possible...

Originally published by April Wendling, University of Illinois at Urbana-Champaign, on February 13, 2024 CRISPR-COPIES has applications in synthetic biology toolkit characterization, gene therapy, and metabolic engineering. Credit: Aashutosh Boob et al. CRISPR/Cas systems have undergone tremendous advancement in the past decade. These precise genome editing tools have applications ranging from transgenic crop development to gene therapy and beyond. And with their recent development of CRISPR-COPIES , researchers at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) are further improving CRISPR's versatility and ease of use . "CRISPR-COPIES is a tool that can quickly identify appropriate chromosomal integration sites for genetic engineering in any organism ," said Huimin Zhao, CABBI Conversion Theme Leader and Steven L. Miller Chair of Chemical and Biomolecular Engineering (ChBE) at the University of Illinois . "It will accelerate ...