Discovery of a hidden epigenetic clock in mitochondria reveals a 'lifespan limit line'
Originally published by Eötvös Loránd University on August 26, 202 N 6 -methyladenine levels in the C. elegans mitochondrial genome gradually increase with age. (A) The 6mA progressively accumulates at different mtDNA sites (mito 3 and mito 4) during aging. (A’) Quantification of the relative mtDNA 6mA levels at different adult stages. Bars indicate ±S.D.; each comparison reveals ***: p < 0.001 significance. Credit: International Journal of Molecular Sciences (2023). DOI: 10.3390/ijms241914858 Building on their work on epigenetics of aging and transposable elements, researchers Dr. Ádám Sturm and Dr. Tibor Vellai from Eötvös Loránd University have made another advance in understanding the molecular mechanisms of aging . Their latest study, published in the International Journal of Molecular Sciences , reveals a novel epigenetic mechanism in mitochondrial DNA (mtDNA) that could transform our approach to aging research and diagnostics . In their previous articles , " T...