Diabetic man produces his own insulin after gene-edited cell transplant

Originally published by Lydia Smith on August 13, 2025

The new proof-of-concept study points a way to curing diabetes without the need for immune-suppressing drugs.

 

A man with type 1 diabetes has become the first patient to produce his own insulin after receiving genetically engineered cell transplants, without needing drugs to prevent rejection.

The case, published this month in the New England Journal of Medicine, marks a potential breakthrough in the treatment of the disease, which affects 9.5 million people worldwide.

Type 1 diabetes occurs when a patient's immune system destroys specialized cells, called islet cells, in their pancreas that are responsible for producing insulin, the hormone that regulates our blood sugar levels. The condition can be managed with regular doses of synthetic insulin, but there is no cure.

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