A Protein Ratio Could Predict Alzheimer’s Disease Progression Decades in Advance
Originally written by Sahana Sitaraman, PhD , at The Sicentist, on March 31, 2025 Current biomarkers of cognitive impairment in individuals with Alzheimer’s disease perform poorly. Now, a stronger predictor emerges. Using data from more than 3000 people, researchers have described a new and more robust protein biomarker to predict cognitive impairment in individuals with Alzheimer’s disease. ©istock, wildpixel In 1906, a 50-year-old woman in Germany died of a mysterious illness. Before her death, she presented with a combination of symptoms that stumped doctors—progressive memory loss, paranoia, confusion, and aggression. A closer look into her brain post-mortem revealed abnormal clumps and tangled bundles of fibers. This was the first documented case of Alzheimer’s disease , described in detail by Alois Alzheimer, a clinical psychiatrist and neuroanatomist. 1 His characterization of the disease pathology is still used for diagnosis of this neurodegenerative dis...