RNA structures present a promising target for early intervention in Parkinson's disease

Originally published by Kumamoto University on November 1, 2024

The trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α-Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α-synuclein aggregation, helping to protect against neuronal function loss. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.09.037

A team of researchers at Kumamoto University has uncovered a mechanism in the formation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's disease.

The team, led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, identified for the first time that unique RNA structures called G-quadruplexes (G4s) play a central role in promoting the aggregation of α-synuclein, a protein associated with neurodegeneration.

The study is published in the journal Cell.

By demonstrating that inhibiting G4 assembly could potentially prevent the onset of synucleinopathies, this discovery positions G4 as a promising target for early intervention in these diseases.

Read more

 

Comments

Post a Comment

Popular posts from this blog

First map of every neuron in an adult brain has been produced for a fruit fly

Image
Originally published by UK Research and Innovation on October 2, 2024   3D rendering of all ~140k neurons in the fruit fly brain. Credit: Data source: FlyWire.ai; Rendering by Philipp Schlegel (University of Cambridge/MRC LMB). The first wiring diagram of every neuron in an adult brain and the 50 million connections between them has been produced for a fruit fly . This landmark achievement has been conducted by a large international collaboration of scientists , called the FlyWire Consortium , including researchers from the MRC Laboratory of Molecular Biology ( in Cambridge, UK ), Princeton University, the University of Vermont and the University of Cambridge . It is published in a pair of papers in Nature . The diagram of all 139,255 neurons in the adult fly brain is the first of an entire brain for an animal that can walk and see . Previous efforts have completed the whole brain diagrams for much smaller brains , for example, for that of a fruit fly larva, whi...
Read more

Research finds resin that destroys coronavirus on plastic surfaces

Image
O riginally published by University of Jyväskylä, on January 30, 2024 Studying the impact of rosin-functionalized plastic and standard LDPE on the structure of HCoV-OC43 using (A) TEM and (B) AFM in liquid. The scale bar corresponds to 100 nm and 1 µm in the TEM and AFM images, respectively. In panel B, the blue circle highlights a doughnut-shaped virus. (C) The histogram derived from the AFM images illustrates the average size distribution of the height of individual viruses after being flushed from their respective surfaces. Credit: Microbiology Spectrum (2024). DOI: 10.1128/spectrum.03008-23 Researchers at the University of Jyväskylä, Finland , are currently developing anti-viral surfaces to decrease the spread of infectious diseases. A recent study published in Microbiology Spectrum found that a resin ingredient is effective against coronaviruses and strongly decreases their infectivity on plastic surfaces. Viruses may persist on solid surfaces for long periods, which ma...
Read more

Engineered Rabies Virus Illuminates Neural Circuitry

Image
Originally published by Hannah Thomasy, PhD, for the Scientist on June 14, 2024 Scientists turned a deadly virus into a crucial tool for understanding the wiring of the brain.   Rabies labeling helps scientists identify neurons in the primary visual cortex that connect to two different higher visual brain regions. Marina Garrett  In 1906 , pathologist Camillo Golgi and neuroscientist Santiago Ramón y Cajal won the Nobel Prize for their work on the structure of the nervous system . More than a century later, the puzzle of nervous system organization —the intricately tangled mess that results from each neuron’s connections to thousands of others— remains incomplete . Yet, fully developing scientific understanding of these connections is crucial , said Edward Callaway , a systems neurobiologist at the Salk Institute . “If you don’t have some knowledge about how the different parts are interacting , there’s no way to generate a hypothesis about how they’re working toget...
Read more