New work on precursors of inflammatory synovial macrophages sheds light on the pathogenesis of rheumatoid arthritis

Originally published by European Alliance of Associations for Rheumatology (EULAR) at MedicalXpress, on June 13, 2024

The exact origin and precursor differentiation route of tissue macrophages remains controversial. At the 2024 congress of EULAR—The European Alliance of Associations for Rheumatology—new work sheds light on blood precursors of pathogenic tissue macrophages


Credito: Unsplash/CC0 Public Domain

Rheumatoid arthritis (RA) is an autoimmune disease that causes joint inflammation and destruction. There is currently no cure—and although there are many treatments, their effectiveness varies from person to person, suggesting an undefined pathogenic diversity.

Deep characterization of myeloid cell subsets by single cell RNA sequencing across healthy and inflamed tissues in RA has led to the identification of new pathogenic cell states and subsets—with data coming from five large-scale studies. But subset overlap across studies and compartments—such as in blood versus synovial tissue—has not yet been systematically investigated.

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