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3D structure of key membrane repair proteins revealed by cryo-electron microscopy

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Originally published by Universitätsmedizin Göttingen, on May 28, 2025 edited by Gaby Clark , reviewed by Robert Egan Cryo-EM micrograph (left) of myoferlin particles (with one particle highlighted circle). 3D reconstruction of the myoferlin structure (right), with compact ring-like arrangement of the various key domains (colored) achieved upon membrane binding. Credit: Biological Reviews (2025). DOI: 10.1111/brv.70032 Researchers from the Göttingen Cluster of Excellence Multiscale Bioimaging (MBExC) have uncovered the 3D structure of the membrane proteins myoferlin and dysferlin using high-resolution cryo-electron microscopy. The findings enable new approaches for the development of targeted drugs for the treatment of diseases such as muscle atrophy, hearing disorders and certain cancers . The results have been published in The EMBO Journal . Read more  
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Mapping tumor microenvironments to predict lung cancer immunotherapy response

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Originally published b y Justin Jackson , Phys.org , on May 27, 2025 edited by Sadie Harley , reviewed by Robert Egan Schematic representation of the mIF assay. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adu2151 Amidst the continued struggle to treat non-small-cell lung cancer , a new study led by Stanford University scientists suggests that a patient's response to immunotherapy may hinge on how immune cells cluster around tumors . Their results reveal that s patial arrangements of certain immune cells within tumors can serve as powerful predictors of treatment response , surpassing existing biomarker tests. Lung cancer leads global cancer mortality , and non-small-cell variants make up more than 80% of cases . Immune checkpoint inhibitors have transformed therapy yet help o nly 27–45% of recipients . Reliable predictive biomarkers for immunotherapy response have eluded clinicians, who currently rely on PD-L1 immunohistochemistry, tumor mutational burden, ...
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