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RNA structures present a promising target for early intervention in Parkinson's disease

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Originally published by Kumamoto University on November 1, 2024 T he trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α -Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α -synuclein aggregation, helping to protect against neuronal function loss. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.09.037 A team of researchers at Kumamoto University has uncovered a mechanism in the f ormation of harmful protein aggregates that lead to neurodegenerative diseases such as Parkinson's disease. The team, led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, identified for the first time that unique RNA structures called G-quadruplexes (G4s) play a central role in promoting the aggregation of α -synuclein , a protein associated with neurodegen

Prolonged brain development of marmosets could serve as model for human evolution

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Originally published by University of Zurich , on October 30, 2024 As in humans, infants of common marmosets interact with several caregivers from birth and are thus exposed to intensive social interaction. Credit: Judith Burkart/UZH The d evelopment of primate brains is shaped by various inputs . However, these inputs differ between independent breeders , such as great apes, and cooperative breeders , such as the common marmoset (Callithrix jacchus) and humans . In these species, group members other than the parents contribute substantially to raising the infants from birth onwards. A group of international researchers led by Paola Cerrito from the University of Zurich's Department of Evolutionary Anthropology studied how such social interactions map onto brain development in common marmosets. The study provides new insights into the relationship between the timing of brain development and the socio-cognitive skills of marmosets , in particular their prosocial and coo

New species of tardigrade reveals secrets of radiation-resisting powers

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Knowing the genes responsible for water bears’ radiation tolerance could lead to diverse applications, from cancer treatment to space exploration. Originally published by   Miryam Naddaf , Nature, on 24 October 2024 The new species is similar in appearance to this Hypsibius sp. tardigrade, photographed using an electron microscope.Credit: Robert Schuster/Science Photo Library A newly described species of tardigrade is giving scientists insights into what makes these tiny eight-legged creatures so resistant to radiation . Tardigrades , also known as water bears , have long fascinated scientists with their ability to withstand extreme conditions , including radiation at levels nearly 1,000 times higher than the lethal dose for humans . There are around 1,500 known tardigrade species, but only a handful are well-studied. Now, scientists have sequenced the genome of a species new to science , and revealed some of the molecular mechanisms that give tardigrades their extraordinary re